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Abstract #2994

Quantification of Macro- And Micro-Vascular Hemodynamics in Cerebral Arteriovenous Malformations During Staged Embolization

Can Wu1, Timothy J. Carroll1, Parmede Vakil1, Sameer A. Ansari2, Bernard R. Bendok2, Hunt Batjer3, Michael Markl1

1Departments of Biomedical Engineering and Radiology, Northwestern University, Chicago, IL, United States; 2Departments of Radiology and Neurological Surgery, Northwestern University, Chicago, IL, United States; 3Department of Neurological Surgery, UT Southwestern, Dallas, TX, United States

4D flow and perfusion MRI were successfully employed to provide quantitative information on both macro- and micro-vascular hemodynamics in AVM patients during embolization. Schematic AVM models were built for macrovascular flow quantification. Contralateral and ipsilateral tissue perfusion was quantified to evaluate the impact of embolization on systemic hemodynamic changes. Spatial co-registration of the 4D flow and perfusion data provides a joint visualization of macrovascular 3D blood flow and microvascular tissue perfusion. The results demonstrate the potential of the joint 4D flow-perfusion MRI method for AVM pre-treatment planning and post-treatment evaluation.