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Abstract #2996

A Parse-MRI Based Technique to Measure Cerebral Oxygen Extraction Fraction (OEF)

Rajiv G. Menon1, Edward G. Walsh2, Donald B. Twieg3, Timothy J. Carroll1, 4

1Radiology Department, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; 2Neuroscience, Brown University, Providence, RI, United States; 3Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL, United States; 4Biomedical Engineering, Northwestern University, Chicago, IL, United States

Oxygen extraction fraction (OEF) is shown to be an independent predictor of stroke. There is an unmet clinical need for a robust MR based OEF measurement technique. A novel PARSE (Parameter Assessment by Retrieval from Signal Encoding) MRI based technique is reported here to measure OEF. We tested the technique on 5 normal subjects and provide anecdotal evidence on an AVM (Arterio-Venous Malformation) patient. Calculated PARSE MR-OEF correlate well with published Positron Emission Tomography (PET) data. Further clinical validation on subjects is required to establish the efficacy of this technique to clinically diagnose stroke risk in a patient.