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Abstract #3003

Quantitative Evaluation of Mismatch in Recanalized Acute Stroke Patients: Comparison Between Arterial Spin Labeling and Dynamic Susceptibility Contrast Perfusion

Kambiz Nael1, Arash Meshksar1, Benjamin Ellingson2, Pablo J. Villablanca2, Noriko Salamon2

1Medical Imaging, University of Arizona, Tucson, AZ, United States; 2Radiological Sciences, UCLA, Los Angeles, CA, United States

Using a pseudo-continuous ASL with background suppression and a 2 second post-labeling delay, ASL performs with only moderate agreement with DSC in quantitative assessment of mismatch classification in revascularized patients with acute stroke. In particular ASL appears less sensitive for detection of reperfusion in successfully recanalized patients. Since the cerebral hemodynamics and arterial arrival time are different in pre and post revascularized patients, different post-labeling delay or ASL methods independent of arterial arrival time (velocity selective ASL) may be needed for better evaluation.