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Abstract #3025

Multispectral Fusion-Based Detection of Virchow-Robin Spaces

Vikas Kotari1, Vasiliki N. Ikonomidou2

1Electrical Engineering, George Mason University, Fairfax, VA, United States; 2Bioengineering, George Mason University, Fairfax, VA, United States

Virchow-Robin spaces are perivascular structures whose dilation can be a biomarker of microvascular disease, vascular dementia, hypertension etc; therefore their detection and characterization may prove useful for disease monitoring. In this study, we present a novel automatic detection technique for VRS detection based on multispectral fusion of information derived from a combination of MPRAGE and T2 weighted images. The approach minimizes noise-driven false positives, resulting in high sensitivity and specificity. The technique is fast and fully automated, making it appropriate for routine use.