Abstract #3039

Calibration of Cerebral Blood Oxygenation and Perfusion MR Imaging in Mice by Invasive Micro Probe Measurements.

Jan Sedlacik¹, Matthias Reitz², Div S. Bolar³, Elfar Adalsteinsson⁴, Nils Ole Schmidt², Jens Fiehler¹

¹Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ²Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; ³Radiology, A. A. Martinos Center , Charlestown, MA, United States; ⁴Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States

Quantitative MR measurements sensitive to blood oxygenation (R2*, QUIXOTIC-R2) and perfusion (Q2TIPS-ASL) were calibrated by different respiratory stimuli and subsequent invasive micro probe measurements. We found reasonable consistency between MRI and micro probe measurements. However, adverse effects of anesthesia and trauma during micro probe insertion have to be solved in further experiments.