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Abstract #3043

Pulsed Continuous 3DASL Cerebral Perfusion Imaging Using Multiple Post Label Delay(PDL) Acq. in the Clinical Utility of Arterial Transit Time(ATT) Mapping: Comparative Study with PET-OEF in Patients with Chronic Occlusive Vascular Disease

Hirohiko Kimura1, Tetsuya tsujikawa1, Tsuyoshi Matsuda2, Yasuhiro Fujiwara3, Kennichi Kikuta4, Hidehiko Okazawa5

1Radiology, University of Fukui, Fukui, Japan; 2Applied Science Laboratory Asia Pacific, GE Healthcare Japan, HIno, Japan; 3Radiology center, University of Fukui Hospital, Fukui, Japan; 4Neurosurgery, University of Fukui, Fukui, Japan; 5Biomedical Imaging Center, University of Fukui, Fukui, Japan

Arterial spin labeling (ASL) is a means of non-invasive MR perfusion assessment that provides a quantitative map of cerebral blood flow. However, it has not been fully investigated whether the hemodynamic changes in patients with occlusive cerebrovascular disease which affects the reliability of ASL-CBF value. The goal of the current study is to demonstrate arterial transit map calculation as well as CBF based on a two-compartment model using a 3DASL with multi-PLD approach. The comparison of CASL-ATT and O15 PET-OEF was also performed for the demonstration of clinical utility of ATT mapping in patients with chronic occlusive cerebrovascular disease.