Abstract #3060

Improving the Consistency in Permeability Measurement with DCE-MRI for Longitudinal Follow-Up of Brain Metastatic Tumors

Yi-Ying Wu¹, Chen-Hao Wu¹,², Chih-Ming Chiang¹, Clayton Chi-Chang Chen¹,³, Jyh-Wen Chai¹,⁴

¹Department of Radiology, Taichung Veterans General Hospital, Taichung City, Taiwan (R.O.C), Taiwan; ²Institute of Biomedical Engineering, National Taiwan University, Taipei City, Taiwan(R.O.C.), Taiwan; ³Department of Biomedical Engineering, Hung Kuang University, Taichung City, Taiwan (R.O.C.), Taiwan; ⁴College of Medicine, China Medical University, Taichung City, Taiwan (R.O.C), Taiwan

Venous output function (VOF) from the larger and straighter superior sagittal sinus, with similar shape of the concentration time curves as AIF, has shown the effectiveness in permeability measurements of brain neoplasms. However, there are still some errors from VOF that may influence the quantification of tissue permeability. The aim of this study is to investigate the clinical applicability of permeability measurement with DCE-MRI, by using a combination of the scaled AIF with VOF and the normalization to the plasma volume of the adjacent white matter, to estimate Ktrans of brain metastatic lesions in the longitudinal follow-up.