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Abstract #3060

Improving the Consistency in Permeability Measurement with DCE-MRI for Longitudinal Follow-Up of Brain Metastatic Tumors

Yi-Ying Wu1, Chen-Hao Wu1, 2, Chih-Ming Chiang1, Clayton Chi-Chang Chen1, 3, Jyh-Wen Chai1, 4

1Department of Radiology, Taichung Veterans General Hospital, Taichung City, Taiwan (R.O.C), Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei City, Taiwan(R.O.C.), Taiwan; 3Department of Biomedical Engineering, Hung Kuang University, Taichung City, Taiwan (R.O.C.), Taiwan; 4College of Medicine, China Medical University, Taichung City, Taiwan (R.O.C), Taiwan

Venous output function (VOF) from the larger and straighter superior sagittal sinus, with similar shape of the concentration time curves as AIF, has shown the effectiveness in permeability measurements of brain neoplasms. However, there are still some errors from VOF that may influence the quantification of tissue permeability. The aim of this study is to investigate the clinical applicability of permeability measurement with DCE-MRI, by using a combination of the scaled AIF with VOF and the normalization to the plasma volume of the adjacent white matter, to estimate Ktrans of brain metastatic lesions in the longitudinal follow-up.