Abstract #3067

Does DCE-MRI Have a Metabolic Dimension?

Martin M. Pike¹, Mohan L. Jayatilake¹, Xiaoyan Wang², Merryl R. Lobo¹, Xin Li¹, Matthias C. Schabel¹, William D. Rooney¹, Dale J. Christensen³, Jerry D. Glickson⁴, Rosalie C. Sears², Wei Huang¹, Charles S. Springer, Jr.¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; ²Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, United States; ³Oncotide Pharmaceuticals, Research Triangle Park, NC, United States; ⁴Radiology, University of Pennsylvania, Philadelphia, PA, United States

The metabolic dimension of DCE-MRI is explored by using targeted therapy on a genetically modified mouse spontaneous breast cancer. DCE-MRI suggests a metabolic flux decrease upon therapy.