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Abstract #3078

Comparison of in vivo and Ex Vivo DTI Cortical Connectivity Measurements in the Squirrel Monkey Brain

Yurui Gao1, 2, Ann S. Choe1, 2, Xia Li1, Iwona Stepniewska3, Adam W. Anderson1, 2

1Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 2Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States; 3Department of Psychological Sciences, Vanderbilt University, Nashville, TN, United States

In a previous study, we validated DTI-tractography-derived measures of primary motor area (M1) corticocortical (CC) connectivity by comparing the ex vivo DTI connectivity with the histological ground truth. Ex vivo acquisitions typically provide higher image quality than in vivo experiments, since scan times can be much longer and motion is usually not an issue. The goal of the present study was to get a more realistic understanding of the limitations of in vivo DTI measures of CC connectivity by comparing the reliability of in vivo and ex vivo DTI data acquired from the same squirrel monkey.