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Abstract #3081

High Spatial Resolution Diffusion Tensor and Kurtosis Analysis of Formalin Fixed Whole Prostate Tissue

Roger Bourne1, Dominic Pang1, Andre Bongers2, Carl Power2, Paul Sved1, Geoffrey Watson3

1University of Sydney, Sydney, NSW, Australia; 2University of New South Wales, Sydney, NSW, Australia; 3Royal Prince Alfred Hospital, Sydney, NSW, Australia

This work compares a high spatial resolution diffusion kurtosis analysis of two whole fixed prostates with single b-value DTI of the same voxels. Kurtosis was found to be high in low diffusivity glandular tissue and low in stromal tissue. Variance of the kurtosis correlated strongly with DTI-derived fractional anisotropy.