Abstract #3081

High Spatial Resolution Diffusion Tensor and Kurtosis Analysis of Formalin Fixed Whole Prostate Tissue

Roger Bourne¹, Dominic Pang¹, Andre Bongers², Carl Power², Paul Sved¹, Geoffrey Watson³

¹University of Sydney, Sydney, NSW, Australia; ²University of New South Wales, Sydney, NSW, Australia; ³Royal Prince Alfred Hospital, Sydney, NSW, Australia

This work compares a high spatial resolution diffusion kurtosis analysis of two whole fixed prostates with single b-value DTI of the same voxels. Kurtosis was found to be high in low diffusivity glandular tissue and low in stromal tissue. Variance of the kurtosis correlated strongly with DTI-derived fractional anisotropy.