Abstract #3099

Diffusion Behaviour of Water and Fat in Bone Marrow

Valentina Di Marco¹, Marco Palombo¹,², Silvia Capuani¹,²

¹Physics Department, Sapienza University, Rome, Italy; ²CNR IPCF UOS Roma, Physics Department, Sapienza University, Rome, Italy

We investigated the potential of Gaussian and non-Gaussian diffusion methods to obtain information about the microstructural complexity and the water compartmentalization in free and trabecular bone-marrow by investigating apparent diffusion coefficient (ADC) of the water and the fat component as a function of diffusion time (&[Delta]). ADCs of the fat were found to be constant as a function of &[Delta], while the intracellular and the extracellular water exhibits a different ADC behavior as a function of &[Delta] in free and trabecular bone marrow. Internal gradient at the interface between water and bone affects extracellular ADC behaviour which is non-Gaussian.