1Neurospin, CEA Saclay , Gif-sur-Yvette, Ile-de-France, France; 2Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; 3Kyoto University Faculty of Medicine, Kyoto, Japan
IVIM MRI images were acquired in 14 rats implanted with a 9L glioma model using a 17.2T MRI scanner. IVIM maps clearly highlighted areas with high and low fraction perfusion within tumors which were generally heterogeneous, as confirmed by histology. Perfusion parameters could easily be obtained using a 2-steps processing approach. Diffusion parameters obtained using a biexponential 2-compartments diffusion model, such as ADCo and fslow, additionally provided information in tissue structure. However, the diffusion parameters estimated from the biexponential model were found to be very sensitive to noise and to the initial values used for data fitting.