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Abstract #3105

Intravoxel Incoherent Motion MR Imaging and Dynamic Contrast-Enhanced MRI in Brain Tumors: Correlation of Quantitative and Semi-Quantitative Parameters

Moritz Jrg Schneider1, Michael Ingrisch1, Birgit Ertl-Wagner, Maximilian F. Reiser, Olaf Dietrich1

1Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, LMU Ludwig Maximilian University of Munich, Munich, Bavaria, Germany

Intravoxel incoherent motion (IVIM) MRI can be used to obtain information about tissue microcapillary perfusion properties based on diffusion-weighted acquisitions. Therefore, we compare perfusion-related parameters obtained by IVIM measurements with cerebral blood volume and flow (CBV,CBF) as well as semi-quantitative parameters retrieved from dynamic-contrast-enhanced (DCE) MRI in tumorous and normal-appearing white matter. The IVIM perfusion fraction f correlates well with CBV and CBF, indicating that IVIM yields perfusion-related information. All of the DCE parameters correlate strongly with the product D*f, which reflects a makeshift flowand is therefore likely to be the best indicator for tissue-perfusion changes.