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Abstract #3142

Numerical Simulation of DMRI Signals in a Complex Tissue Model

Jing-Rebecca Li1, Denis Le Bihan2

1Equipe DEFI, INRIA Saclay, Palaiseau Cedex, France; 2NeuroSpin, CEA, Gif-sur-Yvette Cedex, France

We numerically simulated the magnetization of diffusing water molecules in a two compartment tissue model consisting of permeable cells, with cylindrical and spherical shapes, and extra-cellular space subject to the pulsed gradient spin echo (PGSE) sequence at various diffusion times by numerically solving the Bloch-Torrey partial differential equation using a finite volume spatial discretization coupled with a Runge-Kutta Chebyshev time-stepping method. The simulated results are consistent with experimental findings in rat cortex in vivo.