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Abstract #3183

Accelerated Diffusional Kurtosis Imaging Using Simultaneous Multi-Slice Echo Planar Imaging

Jian Xu1, George Russell Glenn2, Himanshu Bhat3, Stephen F. Cauley4, Kawin Setsompop5, Ray Lee6, Ali Tabesh2, Jens H. Jensen2, Joseph A. Helpern2, Keith A. Heberlein7

1Siemens Healthcare USA, New York, NY, United States; 2Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, United States; 3Siemens Medical Solutions, Charlestown , MA, United States; 4A.A. Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Boston, MA, United States; 5A.A. Martinos Center for Biomedical Imaging, Dept. of Radiology, MGH, Boston, MA, United States; 6Princeton University, Princeton, NJ, United States; 7Siemens Healthcare USA, Charlestown, MA, United States

Diffusional kurtosis imaging extends diffusion tensor imaging by quantifying the non-Gaussian behavior of water diffusion. Established DKI acquisition protocols typically use multi-slice 2D EPI with multiple b-values () and typically 30 gradient directions, which requires 7-15 minutes for full brain coverage. Recently a slice-acceleration method acquiring multiple slices simultaneously with the blipped CAIPIRINHA technique and individually reconstructed using the slice GRAPPA reconstruction method was introduced. In this study, the combination of DKI and the aforementioned multi-slice acceleration technique was performed and initial comparisons of the resultant parametric maps are reported.