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Abstract #3187

Assessing Scan-Rescan Reproducibility of the Parameter Estimates from NODDI

Maira Tariq1, Torben Schneider2, Daniel C. Alexander1, Claudia Angela M. Wheeler-Kingshott2, Hui Zhang1

1Department of Computer Science & Centre for Medical Image Computing, University College London, London, United Kingdom; 2NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom

NODDI (Neurite Orientation Dispersion and Density Imaging) is a recent diffusion MRI technique for directly quantifying microstructual indices of neurites using clinically feasible acquisition. It has been shown to be able to disentangle the key microstructural contributors to the standard measures from diffusion tensor imaging (DTI). This study assesses the scan-rescan reproducibility of NODDI in healthy subjects in comparison to DTI. The results show that NODDI has high reproducibility comparable to that of DTI.