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Abstract #3197

Inter-Vendor Variability in Apparent Diffusion Coefficient Values

Michael A. Levine1, Pavlina Polaskova1, Sara Maria Sprinkhuizen1, Steven M. Stufflebeam1, Bruce R. Rosen1, Jayashree Kalpathy-Cramer1, Elizabeth R. Gerstner1

1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States

Fifteen glioblastoma patients treated with combination cediranib and cilengitide were enrolled in a correlative magnetic resonance imaging substudy. Ventricular apparent diffusion coefficient values were found to be statistically different across vendors. Multi-center clinical trials should be particularly careful to ensure that results acquired from different vendors are comparable.