Abstract #3199

SNR Dependence of Mean Kurtosis and How to Correct It

Elodie Andr¹, Christophe Phillips¹,², Ezequiel Farrher³, Ivan I. Maximov⁴, Farida Grinberg³, Nadim Jon Shah⁴,⁵, Evelyne Balteau¹

¹Cyclotron research center, University of Lige, Lige, Belgium; ²Department of Electrical Engineering and Computer Science, University of Lige, Lige, Belgium; ³Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich, Juelich, Germany; ⁴Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH, Juelich, Germany; ⁵Department of Neurology, Faculty of Medicine, RWTH Aachen University, JARA, Aachen, Germany

The use of high b-values in diffusion kurtosis imaging makes the derived parameters very sensitive to low signal to noise. Here we show the dependence of mean kurtosis on SNR and demonstrate that noise correction is a necessary step, leading to more reproducible metrics.