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Abstract #3211

Impact of Accuracy and Reliability of Diffusivity in Assessing Acute Ischemic Stroke

Venkata Veerendranadh Chebrolu1, Dattesh D. Shanbhag2, Ek Tsoon Tan3, Patrice Hervo4, Marc-Antoine Labeyrie5, Catherine Oppenheim5, 6, Rakesh Mullick2

1Medical Image Analysis Lab, GE Global Research, Bangalore , Karnataka, India; 2Medical Image Analysis Lab, GE Global Research, Bangalore, Karnataka, India; 3GE Global Research, Niskayuna, NY, India; 4GE Healthcare, Buc, France; 5Departments of Radiology and Neurology, Centre Hospitalier, Sainte-Anne, Paris, France; 6Universit Paris Descartes , Paris, France

The b-factor used for DWI imaging could vary due to factors such as gradient non-linearity and concomitant field effects. These system imperfections may differ between different vendors and MRI systems. This variation would impact multi-center studies evaluating the efficacy of the PDM criteria for thrombolysis treatment decision. In this work we demonstrate that in presence of b-factor variability a joint DWI and ADC based method may offer more robust perfusion-diffusion mismatch assessment compared to ADC alone based DWI lesion segmentation method.