Abstract #3236

Deep Brain Stimulation at the Subthalamic Nucleus Produces fMRI Response in the Motor Cortex

Hsin-Yi Lai¹, John Robert Younce¹, Yu-Chieh Jill Kao¹, Hong Yuan², Yen-Yu Ian Shih¹

¹Experimental Neuroimaging Laboraory, Department of Neurology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, NC, United States; ²Department of Radiology, University of North Carolina, Chapel Hill, NC, United States

This study demonstrates unexpected BOLD fMRI response in the motor cortex as a result of DBS at the STN. This response is frequency dependent, peaking at 100 Hz with increased glucose metabolism as confirmed by FDG-microPET. This pattern of frequency-dependence suggests a relationship to the therapeutic effect of STN DBS for Parkinsons disease which may be further investigated by the use of this technique in parkinsonian animal models.