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Abstract #3238

Glucagon-Like Peptide-1 Modulates Functional Magnetic Resonance Imaging Signal Activity in the Rodent Brain

Prasanth K. Chelikani1, Ursula I. Tuor2, David K. Min1

1Gastrointestinal Research Group, Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada; 2Clinical Neurosciences, Radiology, and Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada

The gut hormone Glucagon-like peptide-1 (GLP-1) plays an important role in the regulation of food intake and body weight. However, less is known of the central mechanisms that are engaged by GLP-1 to regulate energy balance. We provide evidence in a novel rat model that IV infusion of an anorexic dose of GLP-1 increases BOLD fMRI activity in homeostatic regions such as the hypothalamus and nucleus tractus solitarius, as well as non-homeostatic regions such as the hippocampus.