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Abstract #3250

On the Spatial Distribution of Cerebrovascular Reactivity During Breath Hold and CO2 Inhalation Tasks as Assessed by Data-Driven Analysis Methods

Ekaterina Tchistiakova1, 2, David E. Crane3, Jeremy Gilbert4, Sandra E. Black3, 5, Bradley J. MacIntosh1, 3

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Heart and Stroke Foundation Centre for Stroke Recovery,, Sunnybrook Research Institute, Toronto, Ontario, Canada; 3Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Research Institute, Toronto, Ontario, Canada; 4Department of Medicine, Division of Endocrinology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; 5Department of Medicine, Division of Neurology, University of Toronto, Toronto, Ontario, Canada


Cerebrovascular reactivity (CVR) can provide valuable information on hymodynamic impairment in a wide range of neurological conditions. In this study we compared the spatial distribution of CVR maps obtained using CO2 inhalation and breath hold (BH) tasks. The two hypercapnic challenges showed a good spatial overlap of CVR maps. Discrepancies were confined to inferior temporal and frontal pole regions with higher sensitivity during BH and CO2 respectively. CO2 CVR presented with increase in regions related to visual processing and sensorimotor areas compared to BH.