Yongquan Ye1, Ewart Mark Haacke1
1Radiology, Wayne State University, Detroit, MI, United States
Resting state fMRI reflects the BOLD signal induced by spontaneous neuronal activities at rest. rs-fMRI signal is especially sensitive to physiological noise, which often is the dominant source of noise. Recently it has been demonstrated that using a flip angle (FA) as low as 9 can reduce the relative weighting of physiological noise in BOLD signal while still sustaining sufficient BOLD contrast . In this study, we will study how different flip angles affect rs-fMRI signal characteristics and the calculation of functional connectivity, and analyze the underlying mechanism of the origin of resting state signals.