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Abstract #3276

Flip Angle Effects on Resting State fMRI Studies

Yongquan Ye1, Ewart Mark Haacke1

1Radiology, Wayne State University, Detroit, MI, United States

Resting state fMRI reflects the BOLD signal induced by spontaneous neuronal activities at rest. rs-fMRI signal is especially sensitive to physiological noise, which often is the dominant source of noise. Recently it has been demonstrated that using a flip angle (FA) as low as 9 can reduce the relative weighting of physiological noise in BOLD signal while still sustaining sufficient BOLD contrast [1]. In this study, we will study how different flip angles affect rs-fMRI signal characteristics and the calculation of functional connectivity, and analyze the underlying mechanism of the origin of resting state signals.