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Abstract #3293

Interhemispheric Structural and Functional Connectivities Show Distinct Strengths of Associations in Homotopic and Heterotopic Connections

Hsin-Long Hsieh1, Pin-Yu Chen2, Fu-Shan Jaw1, Wen-Yih Isaac Tseng2

1Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 2Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan

The structural and functional connectivity are correlated. However, mismatch of functional and structural connectivity occurs due to indirect connections and limitations of current neuroimaging approaches and analysis. To address the limitation, we focus on interhemispheric connection because it is direct connection and the most clearly defined white matter structure. We investigated the interhemispheric structure-function relationship combining DSI and resting-state fMRI. Our results showed that the degree of structure-function relationship varied in different lobes and also differed in homotopic and heterotopic interlobular regions as well. We suggest that topology may be a contributing factor of the structure-function relationship.