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Abstract #3297

Comparison of the Functional Brain Connectivity Network in Night Shift Workers with and Without Shift Work Disorder: A Resting State fMRI Analysis

Siamak P. Nejad-Davarani1, 2, Valentina Gumenyuk3, Hassan Bagher-Ebadian4, 5, Scott J. Peltier2, John Budaj1, Christopher L. Drake3, Douglas C. Noll2, Quan Jiang1, 5, Michael Chopp1

1Neurology, Henry Ford Hospital, Detroit, MI, United States; 2Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States; 3Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, United States; 4Radiology, Henry Ford Hospital, Detroit, MI, United States; 5Physics, Oakland University, Rochester, MI, United States

We have used resting state fMRI to study the functional connectivity network in individuals with Shift Work Sleep Disorder (SWSD) and compared it to the connectivity networks of asymptomatic night shift workers (SWC) and daytime workers (NC). We used a framework in our analysis for segmenting the brain and finding the correlation between the fMRI signals in each segment pair. Our results show differences in the functional connectivity network between the NC and SWC groups however, the connectivity pattern of the SWC group is more correlated to the NC group than the SWSD group pattern which confirms previously reported results.