Abstract #3304

Lateralization of Temporal Lobe Epilepsy Using Resting State Functional Magnetic Resonance Imaging

Jeiran Choupan¹, Zhengyi Yang², Luca Cocchi³, Julia Hocking¹, David C. Reutens¹

¹Centre for Advanced Imaging, Brisbane, QLD, Australia; ²School of Information Technology and Electrical Engineering, Brisbane, QLD, Australia; ³Queensland Brain Institute, Brisbane, QLD, Australia

This abstract focus on finding comprehensive set of measures of functional connectivity in order to improve the localization of the seizure focus in temporal lobe epilepsy patients. The measurement includes resting state functional connectivity, regional homogeneity, amplitude of low frequency fluctuation, fractional amplitude of low frequency fluctuation and voxel-mirrored homotopic connectivity. We have found that, not only the whole brain hippocampal functional connectivity, but also other high level features of resting state fMRI signal, such as regional homogeneity, amplitude of low frequency fluctuation differ between left and right temporal lobe epilepsy groups. These results can be incorporated in pattern classification methods as prior knowledge to increase the classification accuracy.