Hazim Omar1, Theodore Kypraios2, Dorothee P. Auer1, Naranjargal Dashdorj1
1Radiological and Imaging Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom; 2School of Mathematical Sciences, University of Nottingham, Nottingham, Nottinghamshire, United Kingdom
Resting state fMRI had been reported to have small-world architecture in the brain. We investigate the effect of hypnotic and sedative drug, midazolam administration on the functional brain network by using graph analysis and found a small-world network characteristic in both condition pre and post midazolam administration with a significant increase in clustering coefficient which indicate synchronized cliquishness functional network. There is also significant increase in local efficiency which reflects the increase in ability of a network in transmitting the information. This evidence suggests graph theory analysis can provide an insight in exploring the effect in functional brain connectivity.