Assessing the Effect of Midazolam on the Brain Functional Connectivity Using Graph Analysis

Hazim Omar¹, Theodore Kypraios², Dorothee P. Auer¹, Naranjargal Dashdorj¹

Resting state fMRI had been reported to have small-world architecture in the brain. We investigate the effect of hypnotic and sedative drug, midazolam administration on the functional brain network by using graph analysis and found a small-world network characteristic in both condition pre and post midazolam administration with a significant increase in clustering coefficient which indicate synchronized cliquishness functional network. There is also significant increase in local efficiency which reflects the increase in ability of a network in transmitting the information. This evidence suggests graph theory analysis can provide an insight in exploring the effect in functional brain connectivity.