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Abstract #3311

Effects of Oxygen-Enhanced fMRI in the Resting-State Networks

Johnny Ng1, Ying Wei Wu2, Xiaofen Tao2, Edmund Wong1, David Carpenter1, Cheuk Tang1, 3

1Dept. of Radiology, Mount Sinai School of Medicine, New York, NY, United States; 2Dept. of Radiology, Shanghai East Hospital, Shanghai Tongji University, Shanghai 200120, China; 3Dept. of Psychiatry, Mount Sinai School of Medicine, New York, NY, United States

Using pure oxygen as an MR contrast agent (Oxygen-enhanced magnetic resonance imaging) has been used in recent years. It is being used to investigate its effect on brain function and epilepsy in normal controls. However, there is no previous work has studied the effect of oxygen on resting-state fMRI in human. The aim of this study to investigate the difference in activation in the resting-state networks of healthy controls when performing functional scans with and without oxygen enhancement. 26 healthy subjects participated in this study. Significant differences were detected when comparing oxygen enhanced scans versus ambient air scans.