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Abstract #3389

Combination of MR Spectroscopic and Diffusion Weighted Imaging of the Prostate for the Prediction of Tumor Aggressiveness

Josephin Otto1, Gregor Thrmer1, Christian Schrder1, Nikita Garnov1, Lars-Christian Horn2, Minh Hoang Do3, Jens-Uwe Stolzenburg3, Michael Moche1, Thomas Kahn1, Harald Busse1

1Diagnostic and Interventional Radiology Department, Leipzig University Hospital, Leipzig, Saxony, Germany; 2Institute of Pathology, University of Leipzig, Leipzig, Saxony, Germany; 3Department of Urology, Leipzig University Hospital, Leipzig, Saxony, Germany

Active surveillance is regarded as an option to reduce overtreatment in patients with organ-confined low-risk prostate cancer. Transrectal ultrasound-guided biopsy is currently the only method for disease monitoring but has some disadvantages due to its invasive nature and underestimation of tumor dedifferentiation. Multiparametric MRI, on the other hand, can provide quantitative parameters of tissue function that may help to assess tumor aggressiveness. This work evaluates the predictive value of combined DWI and MR spectroscopic parameters to discriminate indolent from aggressive carcinoma.