Abstract #3389

Combination of MR Spectroscopic and Diffusion Weighted Imaging of the Prostate for the Prediction of Tumor Aggressiveness

Josephin Otto¹, Gregor Thrmer¹, Christian Schrder¹, Nikita Garnov¹, Lars-Christian Horn², Minh Hoang Do³, Jens-Uwe Stolzenburg³, Michael Moche¹, Thomas Kahn¹, Harald Busse¹

¹Diagnostic and Interventional Radiology Department, Leipzig University Hospital, Leipzig, Saxony, Germany; ²Institute of Pathology, University of Leipzig, Leipzig, Saxony, Germany; ³Department of Urology, Leipzig University Hospital, Leipzig, Saxony, Germany

Active surveillance is regarded as an option to reduce overtreatment in patients with organ-confined low-risk prostate cancer. Transrectal ultrasound-guided biopsy is currently the only method for disease monitoring but has some disadvantages due to its invasive nature and underestimation of tumor dedifferentiation. Multiparametric MRI, on the other hand, can provide quantitative parameters of tissue function that may help to assess tumor aggressiveness. This work evaluates the predictive value of combined DWI and MR spectroscopic parameters to discriminate indolent from aggressive carcinoma.