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Abstract #3391

Improved Conspicuity and Delineation of High-Grade Prostate Tumors Using "Restriction Spectrum Imaging": Quantitative Comparison with High B-Value ADC

David Karow1, Nate White1, Jiaoti Huang2, Robert Reiter3, Robert F. Mattrey4, Daniel J.A. Margolis5, Steve Raman5, Anders M. Dale6

1Radiology, UCSD, La Jolla, CA, United States; 2Pathology, UCLA, Los Angeles, CA, United States; 3Urology, UCLA, Los Angeles, CA, United States; 4Radiology, UCSD, San Diego, CA, United States; 5Radiology, UCLA, Los Angeles, CA, United States; 6Radiology, University of California, San Diego, La Jolla, CA, United States

Restriction spectrum imaging (RSI) is a sensitive DWI technique for probing separable water diffusion compartments in tissues. Here, we evaluate RSI cellularity maps derived from the spherically-restricted water compartment for improved prostate tumor conspicuity and delineation from non-tumor tissue compared with high b-value ADC. Our data support the MRI-derived RSI cellularity maps as potential non-invasive imaging biomarkers for prostate cancer.