Abstract #3391

Improved Conspicuity and Delineation of High-Grade Prostate Tumors Using "Restriction Spectrum Imaging": Quantitative Comparison with High B-Value ADC

David Karow¹, Nate White¹, Jiaoti Huang², Robert Reiter³, Robert F. Mattrey⁴, Daniel J.A. Margolis⁵, Steve Raman⁵, Anders M. Dale⁶

¹Radiology, UCSD, La Jolla, CA, United States; ²Pathology, UCLA, Los Angeles, CA, United States; ³Urology, UCLA, Los Angeles, CA, United States; ⁴Radiology, UCSD, San Diego, CA, United States; ⁵Radiology, UCLA, Los Angeles, CA, United States; ⁶Radiology, University of California, San Diego, La Jolla, CA, United States

Restriction spectrum imaging (RSI) is a sensitive DWI technique for probing separable water diffusion compartments in tissues. Here, we evaluate RSI cellularity maps derived from the spherically-restricted water compartment for improved prostate tumor conspicuity and delineation from non-tumor tissue compared with high b-value ADC. Our data support the MRI-derived RSI cellularity maps as potential non-invasive imaging biomarkers for prostate cancer.