Abstract #3395

Diffusion-Weighted MRI of the Prostate in Patients with a Significant Family History of Prostate Cancer: Do Histogram Metrics Correlate with Risk?

Maysam Jafar¹, Rosalind Eeles², Sharon L. Giles³, Elizabeth Bancroft², Elena Castro², Veronica A. Morgan³, Catherine J. Simpkin³, Nandita M. deSouza⁴

¹Cancer Research UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom; ²Genetics & Epidemiology, Institute of Cancer Research, Sutton, Surrey, United Kingdom; ³Cancer Research UK and EPSRC Cancer Imaging Centre, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; ⁴Cancer Research UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research & Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

Risk of prostate cancer in first-degree relatives is twice that of the general population; 53 single nucleotide polymorphisms (SNPs) have been associated with clinically significant disease in young patients. Diffusion-weighted combined with T2W MRI is sensitive for detecting small prostate tumours. This study prospectively investigates the relationship between histogram parametrics of the apparent diffusion coefficient (centiles, skew, kurtosis) and risk score (derived from 24 SNPs) and showed no correlation in a preliminary analysis. Inclusion of a larger number of SNPs to generate risk score is planned, as the current data fielded a score of <1 in 55% of the cohort.