Wenchao Cai1, Feiyu Li1, Jing Wang2, Huarui Du2, Jue Zhang2, 3, Xiaoying Wang1, 3, Xuexiang Jiang1
1Department of Radiology, Peking University First Hospital, Beijing, China; 2Peking University, Department of Biomedical Engineering, Beijing, China; 3Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China
Pulsed arterial spin labeling (PASL) MRI is a non-invasive imaging tool capable of quantitatively measuring the microvascular perfusion characteristics of tissue through tagging arterial water to obtain the blood flow (BF) map. Angiogenesis plays a vital role in the metastatic process of prostate cancer, and bone metastasis lesion is hypervascular certificated by dynamic contrast-enhanced (DCE) MRI and histopathologic findings. We applied the PASL technique to detect bone metastasis from prostate cancer and to compare the differences BF values between the metastatic lesions and normal bone in the pelvis. The mean BFs determined by ASL MRI with different TI in the bone metastasis from prostate cancer were significantly higher than those in noncancerous bone regions (P<0.05, Paired T-test) Significant positive correlations between BF value and Ktrans, Kep were observed in all four TI , respectively. ASL is a new non-invasive imaging method with potency in detecting and monitoring therapy efficacy of bone metastasis from prostate cancer.