in vivo Detection and Characterization of 9L Tumors in Rat Brain by BIRDS

Daniel Coman¹, Yuegao Huang¹, Henk M. De Feyter¹, Douglas L. Rothman¹, ², Fahmeed Hyder¹, ²

Development of MRI contrast agents has provided outstanding ability to identify diseased tissue, while MRS has unlocked new windows into molecular bases of diseases. But no magnetic resonance technology exists that can extract quantitative molecular information from a contrasted region. Beyond the gray scale distinction of an affected tissue targeted by an MRI contrast agent we cannot assess the state of the affected tissue because MR signals are compromised by the presence of contrast agents. In this present work we show that TmDOTP^5- can be used as dual contrast agent for tumor detection and molecular MR reporting of cellular status.