Comparison of T1, T2 and T2* Contrast Agents in the Perfusion Assessment of a Glioma Rat Model

Roco Prez-Carro¹, Pilar Lpez-Larrubia¹

Cerebral perfusion assessment by DSC-MRI has become a frequently used tool for evaluation of numerous neuropathologies. The technique is based on the intravenous injection of contrast agent and subsequent bolus tracking using a fast susceptibility-weighted imaging sequence. In this work we to assess the brain perfusion in a glioma rat model by using this technique and four contrast media with different relaxation and plasma half-life properties: a Gd-based T1 agent, a Dy-based T2, and two iron-oxide nanoparticles to enhance T2*-contrast. We show that that Dy chelates provide the best signal to noise ratio and the higher values for hemodynamic parameters.