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Abstract #3420

Monitoring Temporally Selective LDH-A Gene Deletion in Prostate Cancer Using Hyperpolarized Frequency Specific 13C-MRI

Subramaniam Sukumar1, Robert A. Bok2, Daniel B. Vigneron3, Pankaj Seth4, John Kurhanewicz1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; 2Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; 3Radiology and Biomedical imaging, UCSF, San Francisco, CA, United States; 4Medicine, Beth Israel Deaconess Med Center, Boston, MA, United States

Lactate Dehydrogenase expression and activity is up-regulated in various malignancies, including prostate cancer. In a recently developed transgenic mouse model, in which the LDH-A gene is deleted selectively in a temporal fashion, hyperpolarized 13C frequency specific MRI method was used to monitor early changes in LDH-A expression within prostate tumor tissue.