Abstract #3420

Monitoring Temporally Selective LDH-A Gene Deletion in Prostate Cancer Using Hyperpolarized Frequency Specific 13C-MRI

Subramaniam Sukumar¹, Robert A. Bok², Daniel B. Vigneron³, Pankaj Seth⁴, John Kurhanewicz¹

¹Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States; ²Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; ³Radiology and Biomedical imaging, UCSF, San Francisco, CA, United States; ⁴Medicine, Beth Israel Deaconess Med Center, Boston, MA, United States

Lactate Dehydrogenase expression and activity is up-regulated in various malignancies, including prostate cancer. In a recently developed transgenic mouse model, in which the LDH-A gene is deleted selectively in a temporal fashion, hyperpolarized 13C frequency specific MRI method was used to monitor early changes in LDH-A expression within prostate tumor tissue.