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Abstract #3428

Assessment of the Serine Synthesis Pathway During Breast Cancer Progression Using 13C-MRS

Dania Daye1, 2, Suzanne Wehrli3, Chris Sterner, 24, Tien-Chi Pan, 24, Mitchell D. Schnall5, Lewis A. Chodosh, 24

1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA , United States; 2Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, United States; 3NMR Core Facility, Children's Hospital of Philadelphia, Philadelphia, PA, United States; 4Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA, United States; 5Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Among women with breast cancer, tumor recurrence represents the principal cause of mortality. Nevertheless, little is known about the molecular mechanisms underlying how breast cancer recurs. In particular, while dysregulated metabolism has long been recognized as a key feature of cancer development, the metabolic changes accompanying cancer recurrence are largely unexplored. Increased serine biosynthesis has been recently found to be important in tumorigenesis. Yet, no association has been established between this metabolic pathway and cancer progression. In this study, we investigate the differences in serine metabolism between primary and recurrent mammary tumors and assess their role as potential prognostic markers.