Abstract #3453

Quantitative DCE-MRI as a Predictor of Acute Leukemia Response to Therapy

Mohan L. Jayatilake¹, Aneela Afzal¹, Xin Li¹, Yiyi Chen², William J. Woodward¹, Tibor J. Kovacsovics³, William H. Fleming³,⁴, Wei Huang¹

¹Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States; ²Biostatistics, Oregon Health & Science University, Portland, OR, United States; ³Center for Hematologic Malignancies, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, United States; ⁴Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR, United States

Nine newly diagnosed acute myelogenous leukemia (AML) patients underwent DCE-MRI of vertebral body and iliac crest before standard chemotherapy. The pre-therapy bone marrow mean kep was found to be a good predictor of complete remission following therapy. DCE-MRI may be a useful noninvasive imaging method for non-solid tumor cancer studies.