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Abstract #3479

MR Evaluation of Multiple Myeloma at 3.0 Tesla: How Do Bone Marrow Signal Intensity and Selection of Protocols Affect Lesion Conspicuity?

Miyuki Takasu1, Yoko Kaichi1, Miho Ishikawa1, Yuji Akiyama1, Shuji Date1, Akira Sakai2, Yoshiaki Kuroda3, Kazuo Awai1

1Department of Diagnostic Radiology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; 2Department of Radiation Life Sciences, Fukushima Medical University School of Medicine, Fukushima, Japan; 3Department of Hematology, Hiroshima University Hospital, Hiroshima, Japan

The present study compared various imaging sequences in terms of CNR and percent contrast and assessed the dependence of lesion conspicuity on background bone marrow signal intensity in multiple myeloma. Bone marrow-focal lesion CNR and percent contrast in T1-dark marrow were significantly lower when compared with those in T1-bright marrow. Conspicuity of focal myeloma lesion in the spinal bone marrow was dependent on the fat signal fraction in fat-suppressed MRI. No significant difference in lesion conspicuity was found among fat suppression techniques in T1-dark marrow, suggesting the need for a multimodality imaging approach to evaluate focal lesions in multiple myeloma.