Greg O. Cron1, 2, Kawan Rakhra1, 2, Paul E. Beaule1, 3, Isabelle Catelas4, Arturo Cardenas-Blanco1, 2, Ian G. Cameron1, 2, Mark E. Schweitzer1, 2
1Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; 2Radiology, University of Ottawa, Ottawa, Ontario, Canada; 3Surgery, University of Ottawa, Ottawa, Ontario, Canada; 4Mechanical Engineering; Surgery; Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Histological differences have been observed in periprosthetic tissues from metal-on-metal (MM) compared to metal-on-polyethylene (MP) hip implants, suggesting that a perfusion difference might be expected. We developed and applied a quantitative dynamic contrast-enhanced (DCE) MRI technique to measure and compare the perfusion parameter Ktrans (index of flow and permeability) in soft tissues adjacent to MM and MP implants. We demonstrated a trimodal distribution of Ktrans values between tissues from MM and MP implants and observed higher Ktrans values in women. The trimodal distribution remains to be further investigated, however the gender difference is consistent with brain and cardiac perfusion literature.