Rebecca E. Thornhill1, Greg O. Cron2, Mohammad Golfam1, Gina DiPrimio1, Adnan Sheikh1, Eric A. White3, Joel Werier4, Mark E. Schweitzer1
1Medical Imaging, The Ottawa Hospital, Ottawa, Ontario, Canada; 2Medical Imaging, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; 3Radiology, University of Southern California, Los Angeles, CA, United States; 4Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada
Conventional imaging assessment of lipomatous tumors offers limited accuracy to predict malignant potential. We have identified a number of quantitative morphological and textural features that can be extracted from standard T1-weighted spin echo MR images that are capable of delineating lipomas from liposarcomas with 88% sensitivity, 90% specificity and 89% accuracy. These advanced 3 dimensional shape and textural features may identify a 'signature' pattern associated with highly malignant lipomatous tumors and offer improved diagnosis compared to conventional radiologic methods.