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Abstract #3501

Can 3D Shape and Textural Analysis Differentiate Liposarcomas from Benign Lipomas?

Rebecca E. Thornhill1, Greg O. Cron2, Mohammad Golfam1, Gina DiPrimio1, Adnan Sheikh1, Eric A. White3, Joel Werier4, Mark E. Schweitzer1

1Medical Imaging, The Ottawa Hospital, Ottawa, Ontario, Canada; 2Medical Imaging, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; 3Radiology, University of Southern California, Los Angeles, CA, United States; 4Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada

Conventional imaging assessment of lipomatous tumors offers limited accuracy to predict malignant potential. We have identified a number of quantitative morphological and textural features that can be extracted from standard T1-weighted spin echo MR images that are capable of delineating lipomas from liposarcomas with 88% sensitivity, 90% specificity and 89% accuracy. These advanced 3 dimensional shape and textural features may identify a 'signature' pattern associated with highly malignant lipomatous tumors and offer improved diagnosis compared to conventional radiologic methods.