1Department of Radiology, New York University Langone Medical Center, New York, NY, United States; 2Department of Chemistry, New York University, New York, NY, United States
CEST techniques allow the indirect detection of protons associated with chemically exchangeable functional groups. Alteration in the kinetics of several chemical exchange processes in skeletal muscle have been associated with several diseases such as insulin resistance and type 2 diabetes. It is often very challenging to isolate genuine CEST from MT effects that can demonstrate asymmetries with respect to the main water resonance, and can affect quantification of CEST measurements. In this work we demonstrate the in vivo application of a simultaneous two frequency CEST imaging method that allows for MT-independent CEST measurements in the human calf muscle at 7T.