Elli-Noora Salo1, Jari Rautiainen2, 3, Virpi Tiitu4, Mikko A.J. Finnil5, Olli-Matti Aho6, Petri Lehenkari6, Jutta Maria Ellermann7, Simo Saarakkala5, Mikko J. Nissi7, 8, Miika T. Nieminen1, 3
1Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland; 2Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; 3Department of Radiology, University of Oulu, Oulu, Finland; 4Institute of Biomedicine, Anatomy, University of Eastern Finland, Kuopio, Finland; 5Department of Medical Technology, University of Oulu, Oulu, Finland; 6Department of Anatomy and Cell Biology, University of Oulu, Oulu, Finland; 7Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, United States; 8Department of Orthopaedic Surgery, University of Minnesota, Minneapolis, MN, United States
Various quantitative MRI markers have been proposed for the quantitative assessment of articular cartilage degeneration. In this study, the sensitivity of T1, T1Gd, T2, magnetization transfer ratio MTR, continuous-wave (CW) T1&[rho], adiabatic T1&[rho] and T2&[rho], TRAFF and T1 in the presence of saturation (T1sat) to cartilage degeneration was investigated by correlating the MRI parameters with histopathological OARSI grade. ROC analysis revealed high AUCs (0.86-1.00) for all parameters except for MTR. Similarly, good correlation with OARSI grade and MRI parameters were established apart form MTR. Cartilage degeneration was most sensitively detected with TRAFF and T1Gd.