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Abstract #3576

Inhibition Network Differences Between ADHD and Healthy Adults Are Unbiased by Drug Use History

Jerod Rasmussen1, B.J. Casey2, Theodorus GM Van Erp1, Leanne Tamm3, Jeff Epstein3, Claudia Buss1, James Bjork4, James Swanson5, Tim Wigal1, Steven Potkin1

1UC Irvine, Irvine, CA, United States; 2Cornell University, New York, NY, United States; 3Cincinnati Children's Hospital, Cincinnati, OH, United States; 4NIH, Rockville, MD, United States; 5UC Irvine, Irvine, Ca, United States

Persons diagnosed with ADHD in childhood have a higher likelihood of substance abuse at a later age, adding a comorbid factor to attention network deficits brought on by the diagnosis. This work uses the largest sample to date to show that drug use frequency does not bias behavioral and/or cognitive differences when performing a Go/NoGo task. The sample size and multi-site nature of the study make these results especially generalizable.