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Abstract #3581

Atypically Increased Functional Connectivity in Young Adults with Borderline Personality Disorder

Jeong-Won Jeong1, 2, Jeffrey Kuentzel3, Carla D. Chugani4, Harry T. Chugani, 25, Diane C. Chugani, 26

1Pediatrics and Neurology, Wayne State University, Detroit, MI, United States; 2PET center, Children's Hospital of Michigan, Detroit, MI, United States; 3Psychology, Wayne State University, Detroit, MI, United States; 4Counseling and Psychological Services, Florida Gulf Coast University, Fort Myers, FL, United States; 5Pediatrics, Neurology, and Radiology, Wayne State University, Detroit, MI, United States; 6Pediatrics and Radiology, Wayne State University, Detroit, MI, United States


Borderline personality disorder (BPD) is a prevalent mental illness characterized by pervasive instability in emotion, interpersonal relationships, self-image, and behavior. Our previous functional MRI study reported atypically modulated Blood Oxygen Level Dependent signals in young adults with BPD, responding to emotionally congruent and incongruent music-face images. This study utilized topologic network analysis for resting state fMRI in order to investigate which brain networks are mostly affected (or functionally impaired) in young adults with BPD, which might provide an objective tool to quantitatively access atypically organized neural mechanism related to BPD phenotypes.