Abstract #3599

7-Tesla GRE Imaging of Hippocampal Subregion Thickness Is Associated with Symptom Severity and Neurocognitive Deficits in Major Depressive Disorder

Tracy L. Luks¹, Yan Li¹, Angela Jakary¹, Erin Gillung², Natalie M. Holbrook², Stuart Eisendrath², Pratik Mukherjee¹, Sarah J. Nelson³

¹Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States; ²Langley Porter Psychiatric Institute, San Francisco, CA, United States; ³Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, United States

We used 7T MRI gradient-echo imaging to examine the thickness of 2 regions within hippocampal CA1, the cell-body layer stratum pyramidale (SP) and the synaptic layer stratum radiatum/stratum lacunosum-moleculare (SRLM) in Major Depressive Disorder patients, and to test the hypothesis that decreases in these ultra-high field MRI measures of hippocampal thickness would be significantly associated with increases in clinical symptom severity and deficits in memory and attention neurocognitive measures known to involve hippocampal function.