Abstract #3604

Multicomponent Relaxation in Clinically Isolated Syndrome

Hagen H. Kitzler¹, Hannes Wahl¹, Jason Su², Nora Nilles¹, Henning Schmitz-Peiffer³, Tjalf Ziemssen³, Sean C. L. Deoni⁴, Brian K. Rutt²

¹Neuroradiology Department, Technische Universitaet, Dresden, SN, Germany; ²Radiology Department, Stanford University, Palo Alto, CA, United States; ³Neurology Department, Technische Universitaet, Dresden, SN, Germany; ⁴Engineering Department, Brown University, Providence, RI, United States

Multi-component Driven Equilibrium Single Pulse Observation of T1 and T2 (mcDESPOT) was applied on Clinically Isolated Syndrom (CIS) patients in a longitudinal trial to investigate the potential sensitivity of mcDESPOT-derived measures in detecting early and conventionally invisible disease-related myelin loss. The inter-subject variance of MWF was higher than the scanning intra-subject variance proofing the consistency of repeated measurements. Significantly reduced values of Myelin Water Fraction (MWF) were found in white matter lesions and a correlation between time since symptom onset and the decrease of the Parenchymal Volume Fraction (PVF) was revealed in preliminary baseline scans.