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Abstract #3614

Quantitative Susceptibility Mapping of White Matter Hyperintensities in Patients with Traumatic Brain Injury

Wei Liu1, 2, Binquan Wang1, 2, Tian Liu3, Ping-Hong Yeh1, 2, John Graner2, 4, John M. Ollinger2, 4, Hai Pan1, 2, Jamie Harper2, 4, Terrence R. Oakes2, 4, Yi Wang3, Gerard Riedy2, 4

1Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States; 2National Capital Neuroimaging Consortium, Bethesda, MD, United States; 3Biomedical Engineering, Cornell University, New York, United States; 4National Intrepid Center of Excellence, Bethesda, MD, United States

Over 60% of the military patients with traumatic brain injury (TBI) scanned at the National Intrepid Center of Excellence demonstrated T2 white matter hyperintensities (WMH). The high prevalence of WMH in young TBI patients suggests that these WMH may be associated with white matter damage from TBI, although these lesions are non-specific. In-order to determine whether microhemorrhage was present in these WMH lesions, quantitative susceptibility mapping (QSM) was performed in 37 TBI patients. WMH ROIs and control ROIs demonstrated similar apparent magnetic susceptibilities on QSM images suggesting that the WMH observed in these TBI patients may not be associated with iron deposition or demyelination.