Tejasvi Gundapuneedi1, Hao Huang1, Nicholas Hubbard2, Joanna Hutchison2, Bart Rypma2
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; 2Center for Brain Health, University of Texas at Dallas, Richardson, TX, United States
Diffusion Tensor Imaging (DTI) is capable of quantifying white-matter (WM) microstructural changes of patients with neurological diseases such as Multiple Sclerosis (MS). The WM can be generally categorized into four tract groups, commissural, limbic, association and projection tracts, based on their functions. Whereas extensive previous work has documented MS-related WM changes, there has been minimal work investigating the functional consequences of these changes. In this study we assessed the sensitivity of the multiple DTI-derived metrics in these four tract groups to MS WM pathology and performance changes, assessed by neuropsychological measures.