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Abstract #3625

Tissue Cell Fraction (TCF) from Quantitative Sodium MR Imaging Measures Real-Time Tumor Response to Fractionated Radiation Therapy

Keith R. Thulborn1, Ian C. Atkinson1, Aiming Lu1, Saad Jamil1, Wesley McClain1, Matthew Koshy1, Pauliah Mohan2, Kathryn Beal2, Antonio M. Omuro2, Michelle Bradbury2

1Ctr Magnetic Resonance Research, University of Illinois, Chicago, IL, United States; 2Radiology, Memorial Sloan Kettering Cancer Ctr, New York, NY, United States

Quantitative sodium MR imaging and the two-compartment model of tissue sodium concentration have been used to measure weekly and accumulated changes in tissue cell fraction (TCF) of human high grade brain tumors during fractionated radiation therapy. Whereas some tumors show regionally distinct responses within weekly intervals, others show no response. This near real-time capability of early monitoring of tumor responsiveness to treatment could be used to guide adaptive therapy or to switch to more effective alternative therapy. The lack of responsiveness in many of these tumors explains why the prognosis remains so grime for these aggressive tumors.