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Abstract #3636

Cerebral Blood Flow Changes in Glioblastoma Multiforme Patients Undergoing Bevacizumab Treatment Are Seen in Both Tumor and Normal Brain.

Jalal B. Andre1, Seema Nagpal2, Daniel S. Hippe1, Heiko Schmiedeskamp3, Roland Bammer3, Reena Thomas2, Matus Straka3, Lawrence Recht2, Greg Zaharchuk3

1Radiology, University of Washington, Seattle, WA, United States; 2Neuro-oncology, Stanford University, Stanford, CA, United States; 3Radiology, Stanford University, Stanford, CA, United States

The anti-tumoral effects of bevacizumab have been well documented in glioblastoma multiforme, and is attributable in part to it's anti-angiogenic properties. Little attention has been given to the potential alteration in global cerebral blood flow that might results from administration of this therapeutic agent, which is examined in this research.